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CNIs exhibit their immunosuppressive properties by inhibiting the cytoplasmic dephosphorylation of NFAT (nuclear factor of activated T-lymphocytes), thereby preventing it from entering the cell nucleus and triggering downstream cytokine production

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A reduction in the composite primary renal outcome was found with semaglutide compared to placebo

CrossRef Original Articles Diabetes, Obesity and Metabolism The Leg Fat to Total Fat Ratio Is Associated with Lower Risks of Non-Alcoholic Fatty Liver Disease and Less Severe Hepatic Fibrosis: Results from Nationwide Surveys (KNHANES 20082011) Hyun Min Kim, Yong-ho Lee Endocrinol Metab