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By inhibiting the activity of the inhibitory kappa B kinase (IKK), curcumin prevents the translocation and activation of NF-B, thereby reducing the expression of chemokines and pro-inflammatory cytokines such as TNF-, IL-1 and IL-6, which ultimately attenuates inflammatory responses (Jobin et al., 1999)

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The documentation was conducted at zero, 40 and 60 days during the study

(2022) indicated that SAL facilitates Nrf2 activation and promotes the expression of its downstream target genes, which markedly contributes to reducting ROS levels within cells