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81 It has been hypothesised that insulin moves through the blood-brain barrier into the brain and acts as a neuropeptide positively regulating satiety, olfaction, cognition and memory as well as regulating systemic functions such as hepatic glucose production

Three studies contained data for more than one brain region: the results for these different brain regions were included in the final meta-analysis, giving a total of 11 studies in the final list of brain regions with data available

2019;29(3):638652.e5

To be eligible, animals had to have had body composition measured by DXA and had to have reached an endpoint for their weight reduction protocol, in a similar manner to previous studies in cats and dogs 15,16