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It is a crucial antioxidant found in every cell of the body, with particularly high concentrations in the liver, where it plays a vital role in detoxification
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These regulate neuron excitability in the auditory brain, and have the potential to reduce tinnitus in patients with noise-induced hearing loss
Similarly, caffeine and EGCG exhibited significant inhibitory effects on Dusp8 and TGF- 2 , factors in the MAPK pathway that activates protein activity in cascades during the development of NASH ( AP-1, TLR2 , and IL1- , genes that are differentially regulated during the pathological progression of NASH liver inflammation, and SCD1, LEPR , and other genes related to NASH lipid deposition, were regulated by caffeine, but EGCG had no significant regulatory effect
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