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During the 36-week, open-label treatment period, 81.0% of individuals reported adverse events with gastrointestinal (GI) side effects being most common, including nausea (35.5%), diarrhea (21.1%), constipation (20.7%) and vomiting (16.4%)

High purity ensures that the observed biological effects arise from the intended peptide sequence rather than from truncated peptides, synthesis byproducts, or residual reagents

In one major study, participants who used semaglutide alongside lifestyle changes lost about 15% of their body weight over 68 weeksan average of approximately 34 pounds