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[DOI] [PMC free article] [PubMed] [Google Scholar] 73

Moreover, EC 50 values for intracellular Ca 2+ responses in CHO cells are rightshifted by two orders of magnitude compared to cAMP (Koole et al., 2010) and Ca 2+ and cAMP responses are usually measured over different time intervalsan important consideration due to the effect of kinetics on the interpretation of apparent biased agonism (Klein Herenbrink et al., 2016)