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CMS121 was shown to improve memory, and cognitive function in APPswe/PS1 E9 double transgenic mice ( LOX inhibitors 5-Lipoxygenase (5LO) is widely expressed in central nervous system neurons, and its levels increase in an age-dependent manner in the hippocampus and cortex, two brain regions prone to neurodegenerative damage
The partial double bond renders the amide group planar, occurring in either the cis or trans isomers
doi: 10.1210/en.2003-0764
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