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In a negative feedback loop, the HPA axis suppresses the feedback signals transmitted by cortisol to the hypothalamus and pituitary gland in order to decrease CRH and ACTH production, thereby regulating its own secretion level for stress response management ( The administration of Polygonatum sibiricum polysaccharide (PSP) significantly decreased CORT levels in LPS and chronic unpredictable mild stress (CUMS)-induced mice, thereby demonstrating the inhibition of hyperactivity in the HPA axis (Shen et al., 2021)

Fourth, a number of patients withdrew from the study but no causal association can be determined

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This is one of the causes of the sensory symptoms and impairment in motor function that many autistic individuals experience