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Lipid peroxidation then occurs and leads to ferroptosis, which, in turn, causes the damage of intestinal epithelial cells (IECs) and destruction of the intestinal mucosal barrier

The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain treg cell activation and suppression of antitumor immunity

BPC 157 co-administration restated a beneficial effect in the NO-system immobilization (the L-NAME+L-arginine+BPC 157 rats), and BPC 157 overwhelmed the effect of L-arginine as well as the effect of L-NAME and counteracted NO-system immobilization