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Weight loss itself, which can become noticeable in a matter of weeks, can also affect a person's emotions

7, 41984 10.1038/srep41984 [DOI] [PMC free article] [PubMed] [Google Scholar] 96.Ikeda M., Ishima Y., Chuang V.T.G., Sakai M., Osafune H., Ando H.et al

Gradual titration allows GI receptors to accommodate increasing GLP-1R stimulation, significantly reducing nausea, vomiting, and other GI side effects that are most common during rapid dose escalation