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The decrease of glucose consumption leads to the slowing of aerobic respiration process and the increase of intracellular oxygen partial pressure, which may affect macrophage polarization and ROS production

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Cardiovascular death: 2.5% (Wegovy) vs 3.0% (placebo) Heart failure composite: 3.4% vs 4.1% All-cause death: 4.3% vs 5.2% A related study determined that 100 people with obesity would need to be treated for three years to prevent one major cardiovascular event