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The tetrapeptide (AEDG) epitalon, which is also known as epithalon, was first identified in a pineal gland extract and is based on the polypeptide Epithalamin (Khavinson et al 2017

doi: 10.3389/fonc.2025.1576781 Received 14 February 2025 Accepted 16 June 2025 Published 27 June 2025 Volume 15 - 2025 Edited by Sandip Patil, Shenzhen Childrens Hospital, China Reviewed by Francesco Grignani, University of Perugia, Italy Barbara A Osborne, University of Massachusetts Amherst, United States Katia Carneiro, Federal University of Rio de Janeiro, Brazil Madduri Srinivasarao, Purdue University, United States Updates Copyright 2025 Tian, Han, Song, Liu, Shen and Zhong

PlexusDx's Precision Peptide Genetic Test can contextualize these predispositions alongside clinical labs to support personalized provider conversations about optimal dosing and timeline

Some note continued improvement after stopping: consistent with angiogenesis maturation lag