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Sep 13 2021;127(12):1-10

105 HSF2 can regulate the mitochondrial phagocytosis of intestinal epithelial cells via the PARL/PINK1/Parkin pathway, removing damaged mitochondria, decreasing the levels of mtROS in cells, suppressing intestinal mucosal inflammation, and maintaining the intestinal environment balance in UC

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The activation of transcription factors like nuclear factor kappa B (NF-B) and activator protein-1 (AP-1) by ROS is particularly significant in cancer