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For instance, the observed mitigation of microgliosis and pro-inflammatory cytokine release could be directly investigated by co-culturing our hCiPSC-NSCs or their conditioned medium with activated microglial cells (e.g., BV-2 cell line or primary microglia stimulated with LPS/ATP)

"Lipotropic" means fat-moving: these compounds help keep fat from accumulating in the liver, support bile production, and improve how efficiently stored fat is converted to energy

Incubation of isogenic brain organoids with RSL3 for 48 h resulted in a lowering trend of GPX4 protein levels compared to untreated isogenic brain organoids and significantly lower levels of FTH1 ( p = 0.030) (Fig

Methodological differences also contribute to variation: Greenhouse pathogenicity assays and artificial inoculation often impose more uniform and severe disease pressure than natural field infection, whereas field estimates are further modified by sowing time, crop growth stage at infection, and disease escape (Aydodu and Kurbetli 2024)