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Age can also play a role, as older adults may experience more pronounced digestive side effects

Month 2 (Weeks 4-8 post-last injection): The medication should be fully cleared by the end of this month (for semaglutide or tirzepatide)

The agency permits some unapproved drugs to be marketed if they are relied on by health care professionals to treat serious medical conditions when there is no FDA-approved drug to treat the condition or there is insufficient supply of FDA-approved drugs. Given these complexities, ideal patient candidates for Retatrutide include individuals with significant obesity, persistent insulin resistance, and metabolic syndrome who have not adequately responded to other medically supervised weight-loss strategies and who clearly understand the investigational status of the medication

doi: 10.1523/JNEUROSCI.1907-15.2016, 2 AgostinhoP.CunhaR