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Annu Rev Physiol (2022) 84:43559

[20] As a result, mycotoxins have been associated with increasing the risk for all-cause morbidity [21] and worsening the symptoms of several diseases, including IBS, arthritis, Alzheimers disease , autoimmune, HIV [22] , heart and liver diseases, respiratory conditions, cancers, diabetes, and obesity

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240 Furthermore, the expression of enzymes in the NAD + salvage pathway, including Nmrk1, Nampt, and Nadk, has circadian oscillation patterns in WT and Liver-RE mice that exclusively express BMAL1 in the liver, suggesting the circadian clock might reprogram NAD + salvage synthesis to maintain the fluctuation of NAD +