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The benefit of GSH pre-treatment demonstrated here provides additional evidence that oxidative damage likely contributes to ITZ-associated hepatotoxicity

Copper is a cofactor of enzymes important for connective tissue, including: lysyl oxidase (cross-linking of collagen and elastin) and superoxide dismutase (SOD) antioxidant enzyme

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In addition, ARNTL2 knockdown decreases N-cadherin expression and increases the expression of -catenin and E-cadherin in lung adenocarcinoma cells, while the opposite effects are observed in ARNTL2-overexpressed cells, 118 suggesting that ARNTL2 overexpression may promote EMT by inhibiting ferroptosis