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Incretin based therapies, such as glucagon-like peptide-1 (GLP-1) receptor agonists mimic the hormone that originates from the small intestine and is released in response to nutrition intake

This novel method produced medicines that are capable of sustaining therapeutic drug levels for a minimum of 24 h, facilitating once-weekly administration for the majority of these drugs (Holst 2019)

More recently there has been cautious optimism among groups who believe that some studies were perhaps stopped prematurely and that while monotherapies might not be the way forward, combination therapies may hold greater promise [54,57,58,59]