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In animal models of stroke, endothelial proliferation has been reported as early as 1224 h (139), while active angiogenesis, with the consecutive maturation and stabilization of blood vessels, has been proven to occur around 34 days after injury in AIS patients (196)

Furthermore, cells in several types of cancers are characterized by significant enhancement of glutathione biosynthesis, and this metabolic vulnerability has been targeted to sensitize these cancer cells to ROS-induced drugs 63

The compound also appeared in hair care formulations targeting hair follicle research endpoints

i.e., they were not necessarily acting primarily as antioxidative enzymes