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GPx4, lipid peroxidation, and cell death: Discoveries, rediscoveries, and open issues

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Using the arginine deiminase analog ADI-PEG-20 in hepatocellular carcinoma and glioblastoma has demonstrated antitumor activity in vitro and in xenograft models and demonstrated safety and efficacy in a phase I clinical trial

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GGT2 also exhibits abnormal expression in tumors (30) and upregulating GGT2 can overcome H2O2-induced apoptosis (35)

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