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The combination AZT plus indinavir induced an increase in ROS production, disruption in membrane mitochondrial potential, reduction in intracellular GSH levels, augment permeability of endothelial layer, leading cell death [49]

For example, presequence proteases (conserved components of mitochondrial proteostasis), identified as Arabidopsis thaliana presequence protease 1 (AtPreP1) and presequence protease 2 (AtPreP2) in Arabidopsis and presequence protease (PITRM1) in mammals, have similar functions in mitochondrial protein quality control in both systems

Composed of three amino acidsglutamine, glycine, and cysteineit plays a crucial role in protecting cells from oxidative stress, detoxifying harmful substances, and supporting overall cellular health

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