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In weight loss clinical trials, semaglutide helped people lose about 15 percent of their body weight on average significantly more than the currently available obesity drugs and more than enough to improve health outcomes

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Postmarket safety profile of suicide/self-injury for GLP-1 receptor agonist: a real-world pharmacovigilance analysis Published online by Cambridge University Press: 30 November 2023 Abstract Recent reports of individuals experiencing suicidal and/or self-injurious behaviors while using liraglutide and semaglutide have heightened the concerns regarding neuropsychiatric safety of Glucagon-like peptide-1 agonists (GLP-1RAs)