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Supplementary Material Acknowledgments The authors would like to thank pharmacists Sarit Carmi and Shira Shalit, from the Division of Clinical Pharmacy, Institute for Drug Research, School of Pharmacy, Hebrew University and Hadassah Medical School, Jerusalem, Israel, for their valuable contribution to the data collection, done while acquiring their PharmD degree

Weight loss with GLP-1 agonists continues accumulating through week 60+

Following 2 weeks of liraglutide/saline treatment, mice were fasted overnight (12 hours) and given a last dose of liraglutide/saline at 08:00

Hybrid drugs integrate heterogeneous active units