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Bulletin of Experimental Biology and Medicine

Gleiter CH, Schreeb KH, Freudenthaler S, et al

The causes of desire loss Lack of quality sleep, high stress, poor diet, poor physical health, medications and birth control pills, low physical activity, unresolved conflicts, repressed emotions, depression, and anxiety, past sexual abuse, poor self-image and lack of self-confidence, infidelity, and menopause (or other hormonal imbalances like low thyroid) are the main psychological and emotional causes of low sex drive in men and women

Therefore, decreased NCOA4 expression and impaired binding of NCOA4 to FTH1 diminish the FTH1 degradation by downregulating ferritinophagy, and decreased FPN1 expression inhibits iron output and release to other tissues, both of which effectively increase liver iron overload and, in turn, trigger oxidative stress and ferroptosis (82)