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Acknowledgements The authors thank their funding agencies, the Singapore Ministry of Health, Ministry of Education and Ministry of Trade, the National Medical Research Council, Singapore, and the Singapore Agency for Science, Technology and Research, for grants NMRC/CSA/0054/2013 (P.M.Y.), NMRC/BNIG/2025/2014 (R.A.S.), IA/I/16/2/502691-Wellcome Trust/DBT India Alliance Intermediate Fellowship (R.A.S.) and NMRC/OFYIRG/0002/2016 (B.K.S.)

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The alkaloid content of Ephedra species is highly variable, depending upon the type, the parts of the plant used and the method of extraction, the most represented being ephedrine and its stereoisomer pseudoephedrine (Fig

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