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Why do trials for Alzheimer's disease drugs keep failing

10.1038/s42003-024-06226-1 7 ChenC.ZhaiE.LiuY.QianY.ZhaoR.MaY.et al (2023)

One important mechanism that controls redox homeostasis and guards against ferroptosis is the Nrf2/ARE pathway ( Ferroptosis inhibitors have been shown in preclinical research to lessen lung damage in ARDS animals

Pharmaceutical interventions targeting this system aim to restore or augment pulsatile GH secretion while preserving the physiological feedback mechanisms that prevent sustained supraphysiologic GH exposure

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