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43 These interactions enable lactate to regulate cytokines, chemokines, adhesion molecules, and signaling pathways (Figure 1) for the expression of several enzymes taking part in immune response and metabolism, elucidating its differential effects on inflammatory processes beyond its role as a well-known metabolic waste product

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Cys 2 ), cystine-free (Cys 2 -free), or cystine-free/GSH-supplemented (750 M) medium, untreated or treated with BSO (100 M) for 72 h, and relative cell numbers were determined