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Proteomics data are available via ProteomeXchange with the identifier PXD042314 ( Abbreviations ASD: autism spectrum disorders CNS: central nervous system CGI: Clinical Global Impression DEGs: differentially expressed genes DEPs: differentially expressed proteins EV: extracellular vesicles FC: fold change GCP: Good Clinical Practice GO-BP: Gene Ontology-Biological Process GSEA: Gene Set Enrichment Analysis IRB: Institutional Review Board LR: ligandreceptor LCMS/MS: liquid chromatography tandem mass spectrometry MCID: minimal clinically important difference NK: natural killer NTA: nanoparticle tracking analysis PBMCs: peripheral blood mononuclear cells PBS: phosphate-buffered saline PD: Proteome Discoverer pDCs: Plasmacytoid dendritic cells PHGDH: Phosphoglycerate dehydrogenase SEM: standard error of the mean TADA: Transmission and de novo Association WGCNA: Weighted gene co-expression network analysis References Maenner, M
Enhances liver detox and metabolic function
Animals fed with excess iron demonstrate increased lipid peroxidation, BBB breakdown, altered mitochondrial dynamics, -amyloid deposition, tau hyperphosphorylation, and loss of dendritic spine densityreminiscent of AD pathology (Sripetchwandee et al., 2014, 2016)
Growth hormone and IGF-1 are also fundamental in skeletal growth during puberty
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