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Additionally, a decrease in testosterone levels was observed in male participants, the clinical significance of which requires further investigation in relation to gonadal function and changes in body composition

10.1038/s41591-024-03412-w 117 XuX.FukuiH.RanY.TomitaT.OshimaT.WatariJ.et al (2019)

Its not the ingredient

For accurate determination of insulin secretion, independent of varying hepatic insulin extraction, it may be useful to measure plasma levels of C-peptide, proinsulin's connecting peptide, which is not extracted in the human liver

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