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albicans utilisation of arginine or proline as the sole carbon and nitrogen source (Fig

Glutamine is the major source of ammonium produced in cultured cells Because the bulk (90%),[1,3-5] of the ammonium produced by cells in culture derives from glutamines 2 nitrogen moieties (preformed DMEM media glutamate is 1, Figure 1, and consistent with glutamate (glutaminolysis) supporting anaplerosis (Figure 2)

Precursors of GSH or GPX biosynthesis, various small molecule activators related to the GSH system and some novel therapeutic approaches, such as exosomes and gene therapy, can boost the activity of the GSH system and reduce cardiac damage and ferroptosis

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