No clinical evidence shows direct interference between the two compounds' hormone-releasing pathways
Effect of high-dose ibuprofen on 24-hour blood pressure in healthy women
2+ /calmodulin (CaM)-dependent protein kinase kinase/CAM-dependent protein kinase IV/Prolactin regulatory element binding (CaMKK/CaMKIV/PREB), increasing apolipoprotein AI (apo AI) mRNA and promoter expression, and increasing apo AI secretion, thereby mediating intracellular cholesterol efflux
According to the Mayo Clinic, some of these possible interactions include: Substrates for cytochrome P450 2C9, such as Valium (diazepam) and Jantoven (warfarin) Some diabetes medications Evista (raloxifene) Olysio (simeprevir) Rapamune (sirolimus) Other medications, such as those that treat allergies, high cholesterol, anxiety, and cancer, could also interact with milk thistle, according to Mount Sinai