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Collectively, following the SP@M treatment, oxidative stress, inflammatory response, and osteoclast differentiation were regulated, which restored the osteoimmunology homeostasis for RA alleviation

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Collagen and Extracellular Matrix Remodeling GHK-Cu activates fibroblasts, increasing the synthesis of: Type I and III collagen Elastin Proteoglycans Glycosaminoglycans (including hyaluronic acid) This mechanism helps restore structural integrity, improving firmness, elasticity, and volume over time

As a consequence, IGF-1 is synthesized and secreted at suboptimal levels