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212 Similarly, Cristina Gonzalez-Correa et al found that in a mouse model of systemic lupus erythematosus, TMAO may induce elevated NADPH oxidase activity and vascular endothelial oxidative stress by inhibiting Nrf2-mediated antioxidant defense mechanism

Correlates of neuroplasticity associated with opioid intoxication depend upon NO signaling (Peregud et al., 2016), and altered (mostly increased) NOS expression and NO synthesis during opioid withdrawal that correlate with behavioral symptoms occur in many addiction relevant brain regions (Leza et al., 1996