These in vitro findings support the notion that ALC decreases cholesterol synthesis by downregulating SREBP2, thereby contributing to its lipid-lowering effects observed in vivo
(C) Using murine models and in vitro studies with bacteria derived from humans, several bacterial genera were identified as producers of 3-oxoLCA, including Gordonibacter pamelaeae P7-E3, Eggerthella lenta P7-G7, Raoultibacter massiliensis P7- A2, Collinsella intestinalis P8-C1, Adlercreutzia equolifaciens P11-C8 , and Clostridium citroniae P2-B6
People who have very little weight loss may still get real benefit for treating cardiovascular and liver disease, sleep apnea, and a range of inflammatory and neurological diseases
In a large study involving 12,548 propensity matched type 2 diabetes patients from three U.S.-based insurance claims databases, addition of an SGLT2 inhibitor to background therapy with GLP-1 receptor agonist reduced the composite CV outcome by 24%, myocardial infraction by 29% and all-cause mortality by 32% (Dave CV, et al
