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Quantification was accomplished by comparing the peak area of free F2-Isoprostanes with that of the corresponding deuterated internal standard

A great effort has been paid to find drugs and treatments for hospitalized, severely ill patients

Mechanistically, Nrf2 activation leads to transcriptional activation of antioxidant enzymes, including microsomal epoxide hydrolase, heme oxygense-1 (HO-1), NADPH: quinone oxidoreductase 1 (NQO-1), and glutamate cysteine ligase (GCL), which catalyzes the initial and rate-limiting step in GSH synthesis