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1998 reported low-nanomolar GHS-R1a binding affinity and growth hormone release at potency comparable to GHRP-6 in rat pituitary cells, anesthetized rats, and conscious swine, with no detectable elevation of plasma ACTH, cortisol, prolactin, FSH, LH, or TSH at doses greater than 200-fold above the GH ED50 [3]

The theory is that the bodys signaling pathways reach their limit at low concentrations regardless of body size

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