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The key molecules in signaling pathways associated with glycolysis (e.g., PDK4), OXPHOS (e.g., IDH1 and KG), glutaminolysis (e.g., glutaminase), PPP (e.g., G6PD and NADPH), and P53 pathway are critically involved in regulating ferroptosis in ovarian cancer [12]

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Meng et al., 2024), we hypothesize that in SLI, modulating METTL3 may alter the expression of ferroptosis-related factors by influencing the m6A modification levels of genes involved in lipid metabolism and antioxidant defense, thereby regulating hepatocyte ferroptosis and contributing to disease progression (Figure 4)