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GIP receptor activation adds a second layer

Instead, research points to activity across multiple interconnected systems, including modulation of the nitric oxide (NO) system, upregulation of growth factor expression (notably VEGF, EGF, and FGF pathways), promotion of angiogenesis, and activation of the FAK-paxillin signalling pathway involved in cell migration and tissue organisation

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Reactive astrocytes have been shown to exert cytotoxicity, and as their activation intensifies, astrogliosis contributes to pathological features such as fibril accumulation, vascular damage, and BBB disruption (Liddelow et al., 2017