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These signals include peptides secreted by the gastrointestinal tract (CCK, GLP-1), the pancreas (glucagon and insulin) and adipose tissue (leptin)

That suggests Novo Nordisk agreed to entry date for the generics before June 2033, i.e., the expiration date of the 462 patent

The result isn't dramatic collapse it's a slow, persistent drag on your energy that's easy to blame on sleep, stress, or aging