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Nrf2 is involved in not only the regulation of GSH synthesis and reduction via upgrading some enzymes and proteins (SLC7A11, GCLM, GCLC, GR) but also the activation of GSH-dependent antioxidant enzymes (GPX, GST) [200, 201]
Morphological characteristics of ferroptosis The morphological characteristics of ferroptosis primarily encompass disruptions in plasma membrane integrity, swelling of cytoplasm and organelles, and chromatin condensation
It sensitizes tumors by inhibiting PARP1-mediated autophagy while reducing cisplatin-induced organ damage
They said the IV therapy made a huge difference
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