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These fragments stimulate inflamed synovium cells (synoviocytes, macrophages, lymphocytes) to secrete cytokines, chemokines, and lipid mediators, as well as more ROS and MMPs, which can directly degrade the components of the cartilage matrix or dysregulate the metabolism of chondrocytes, leading to an imbalance between cartilage matrix degradation and synthesis

Sridharan K, Sivaramakrishnan G, Sequeira RP, Elamin A

UTX negatively regulates the expression of ATF4 and its downstream target genes, such as ChaC1, by maintaining histone marks that prevent their activation

A method for combining RNAscope in situ hybridization with immunohistochemistry in thick free-floating brain sections and primary neuronal cultures