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Utilizing advanced drug delivery systems, such as nanoparticles, may also enhance the targeting and absorption of GST inhibitors, potentially addressing differences in absorption rates across diverse populations

In simian immunodeficiency virus (SIV)-infected rhesus macaques, treatment with selegiline (monoamine oxidase inhibitor) and L-DOPA during peak viremia significantly enhanced viral infection and neuropathology in the basal ganglia, frontal cortex, and hippocampus at 6 to 8 weeks postinfection (Czub et al., 2001, 2004)