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They found that even without causing weight loss, retatrutide had anti-tumor effects that were similar to the currently used (and incredibly expensive) immunotherapy.[ref] A 5-year mortality study in colon cancer patients showed that GLP-1 RA use decreased mortality risk by 60% in obese patients.[ref] Animal studies may show the mechanism

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If you find it uncomfortable during escalation, discuss dose timing or escalation rate with your prescriber though formal dose-reduction protocols for heart rate specifically have not been published