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SN Comprehens Clin Med 3(4):10311041 Drucker DJ (2018) Mechanisms of action and therapeutic application of glucagon-like peptide-1

The four peptides were suspended in Krebs buffer containing 0.2% w/v BSA and 0.03% w/v bovine bile, at various concentrations to obtain a dose response curve, and incubated on the NCI H716 cells for 2 h

It mimics this hormone's effects on blood sugar control and appetite regulation

Such pulsatile signaling resulting from intermittent release of GHRH from neurosecretory hypothalamic neurons consistent with prior and concurrent hypothalamic somatostatin tone preserves biosynthesis and secretion of somatotropin