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We collected the l-EV fraction from HEK293 cells expressing the MIM I-BAR domain and applied these EVs to WT and CIP4 KO cells as described above (Fig

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(89), through a 60-day prospective, experimental, controlled, double-blind study with 60 patients diagnosed with chronic migraine, predominantly women, observed that omega-3 PUFAs intake led to a significant reduction in headache days, indicating the benefit of omega-3 PUFAs in migraine prophylaxis

The GLP-1 receptor is expressed primarily in pancreatic beta cells, the gastrointestinal tract, and certain areas of the central nervous system, with limited expression in skeletal muscle tissue