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53 Future Directions Migraine and mood disorders are highly comorbid conditions, both of which appear responsive to ketamine treatment, which raises the need for more research into the role of the glutamatergic pathway in migraine pathophysiology, as has been done for major depressive disorder and stress processing

Acetaminophen, in particular, is known to produce a toxic metabolite that is normally detoxified by glutathione

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This part is influenced by things like stomach acid, gut health, digestive enzymes, transporters, fibre, and competition with other nutrients