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A recent cryoEM study, for the first time, characterized the structure of full-length AR and defined interaction sites between AR NTD and key AR coregulators p300 and SRC3 [48]

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If a switch is needed, psychiatrists typically look at: Why you're switching: activation, sedation, sexual side effects, poor response, weight concerns How sensitive you've been to dose changes Whether the current medication should be tapered, cross-tapered, or replaced more directly What else you're taking A safe switch is usually a planned medical decision, not something to improvise based on internet advice