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Cytokines have been shown to sensitize knee joint nociceptors to mechanical stimulation in rats 47

60 HP 95 DSIP Delta Sleep-Inducing Peptide ALIASES DSIP, delta sleep-inducing peptide, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu CLASS Endogenous nonapeptide sleep / stress-pathway modulator FORMULA C35H48N10O15 SEQUENCE Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu HALF-LIFE Very short (minutes) plasma longer CNS retention reported ROUTES Subcutaneous (research) Intranasal (research) MECHANISM OF ACTION Nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) originally isolated from rabbit cerebral venous blood during electrically induced sleep states

also showed that NK cells are more resilient against glutamine depletion and still produced interferon- in a glutamine-limited setting [150]

This detoxification capacity may allow S