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Preliminary observations from a Phase III clinical trial (NCT02896192) suggested that among 10 patients with POMC -deficient obesity (aged 6 years, BMI 30 kg/m 2 ), approximately 80% achieved a weight reduction of 10% after 1 year of treatment with setmelanotide following individualized dose titration

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The hormones produced by the enzymatic processing of proglucagon then play essential roles in glucose metabolism and homeostasis [8, 9]

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