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Transformation into secondary BAs largely depends on the action of gut microbiota

Genetic mouse models deficient in other TAG lipases will also be needed to determine their relative contribution to lipolysis

Chronic conditions impacting absorption include atrophic gastritis or pernicious anaemia, where there is a lack of intrinsic factor, a protein essential for the uptake of B12 in the digestive tract

In contrast, DIO mice in both groups switched from WD to LD each had significantly increased Proteobacteria relative abundance (represented solely by the genus Parasutterella ) compared to both the WD and the LD controls, suggesting that Proteobacteria relative abundance may be largely influenced by stress or the differences in net energy expenditure (or associated body weight changes) caused by the diet switch